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KMID : 0381120140360060701
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Genes and Genomics
2014 Volume.36 No. 6 p.701 ~ p.709
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Detection of a distinct variation site for geographical classification of mitochondrial DNA haplogroup A in the domestic goat (Capra hircus)
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Kim Jae-Hwan
Byun Mi-Jeong
Choi Seong-Bok
Suh Sang-won
Kim Young-Sin
Kim Myung-Jick
Ko Yeoung-Gyu
Cho Chang-Yeon
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Abstract
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Domestic goats (Capra hircus) are classified into six different mitochondrial DNA (mtDNA) haplogroups (A, B, C, D, F, and G), of which haplogroup A shows worldwide distribution. However, there is currently no key for genetic and geographic classification of haplogroup A. In this study, we determined the complete sequences of the mtDNA control region from Korean native goat breeds. In addition, we compared these sequences with those of other domestic goat breeds/populations globally. A distinct variation site was found at position 717. Of two types (C and T) from this variation, C type sequences were found only in haplogroup A, and were specific to Eastern Asia. On the other hand, T type sequences were distributed in all haplogroups. Phylogenetic analysis divided the two types according to different phylogenetic locations. These results suggest that a variation in position 717 is a key for geographical classification of mtDNA haplogroup A. Moreover, these distribution patterns might provide for identification of the maternal origin of goat genetic resources, including Korean native goat breeds.
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KEYWORD
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Domestic goat, Haplogroup, Control region, Geographical, Phylogenetic analysis
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